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KMID : 1812720230050020082
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International Journal of Heart Failure
2023 Volume.5 No. 2 p.82 ~ p.90
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SGLT-2 Inhibitors in Heart Failure: A Review of Current Evidence
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Khawaja M. Talha
Stefan D. Anker
Javed Butler
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Abstract
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Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are the latest addition to guideline-directed medical therapy in heart failure (HF) with reduced ejection fraction with recent trials suggesting a significant reduction in adverse cardiovascular outcomes in patients with HF with mildly reduced and preserved ejection fraction. SGLT-2 inhibitors have evolved as metabolic drugs due to their multi-system effects and are indicated for the management of HF across the ejection fraction spectrum, type 2 diabetes, and chronic kidney disease. There is ongoing research to explore the mechanistic effects of SGLT-2 inhibitors in HF and to evaluate their use in worsening HF and after myocardial infarction. This review focuses on the evidence for SGLT-2 inhibitors from type 2 diabetes cardiovascular outcome and primary HF trials and discusses ongoing research related to their use in cardiovascular disease.
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KEYWORD
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Sodium-glucose transporter 2 inhibitors, Heart failure, Systolic, Diastolic
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